crizotinib boosts amounts of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Dose reduction could be necessary for coadministered prescription drugs which are predominantly metabolized by CYP3A.posaconazole will boost the level or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metaboli

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